วารสารวิชาการ “งานวิจัยโรคมะเร็ง” ของสหรัฐฯ เปิดเผยว่า นักวิจัยมหาวิทยาลัยแคลิฟอร์เนีย ซานฟรานซิสโก ได้ยุให้ผู้ป่วยด้วยโรคมะเร็งของต่อมลูกหมากที่เพิ่งเป็นต่อสู้กับโรคด้วยการเดินเร็วๆ ไม่ใช่เดินแบบธรรมดา อาทิตย์ละไม่ต่ำกว่า 3 ชม. จะชะลออัตราการเติบโตของโรคลงได้ตั้งครึ่ง ทั้งยังจะต้านโรคไม่ให้ลุกลามออกไปได้นานถึง 2 ปี
นักวิจัยได้สังเกตพบจากคนไข้ชาย ส่วนใหญ่ วัย 60 ปี 1,455 คน ที่เพิ่งได้รับการวินิจฉัยโรคว่า เป็นมะเร็งของต่อมลูกหมากคงที่ หมายความว่า ยังไม่ลุกลามออกไป พวกเขาได้ซักถามถึงการออกกำลังของแต่ละคน และชนิดใดในแต่ละสัปดาห์
ระหว่างที่ติดตามดูอาการอยู่นานเป็นเวลา 31 เดือน นักวิจัยได้บันทึกได้ว่า มีผู้ป่วยรายที่มีอาการกลับมาอีก และที่เกิดเป็นมะเร็งกระดูกจนเสียชีวิตลง รวมทั้งหมด 117 กรณี แต่กับพวกคนไข้ที่ออกกำลังด้วยการเดินเร็ว อาทิตย์ละไม่ต่ำกว่า 3 ชม. มีอยู่เพียงไม่กี่คน
หัวหน้านักวิจัยกล่าวว่า “ดูเหมือนว่า คนไข้ที่ได้เดินเร็ว อาจจะไปต้านหรือถ่วงการดำเนินของโรคไว้ได้” ประโยชน์ของมันอยู่ตรง เดินไวขึ้นเท่าไหร่ หากเดินเนิบๆ ธรรมดาดูเหมือนจะไม่ได้อะไร.
SAN FRANCISCO — A study of 1,455 U.S. men diagnosed with early-stage prostate cancer has found a link between brisk walking and lowered risk of prostate cancer progression, according to scientists at the University of California, San Francisco and the Harvard School of Public Health.
The scientists found that men who walked briskly — at least three miles per hour — for at least three hours per week after diagnosis were nearly 60 percent less likely to develop biochemical markers of cancer recurrence or need a second round of treatment for prostate cancer.
“The important point was the intensity of the activity — the walking had to be brisk for men to experience a benefit,” said Erin Richman, ScD, a postdoctoral fellow at UCSF who is the first author on the study, published today in the journal Cancer Research. “Our results provide men with prostate cancer something they can do to improve their prognosis.”
An earlier study, published earlier this year by UCSF’s June Chan, ScD, and collaborators at the Harvard School of Public Health, showed that physical activity after diagnosis could reduce disease-related mortality in a distinct population of men with prostate cancer. The new study complements this finding, as it was the first to focus on the effect of physical activity after diagnosis on early indications of disease progression, such as a rise in prostate-specific antigen (PSA) blood levels.
“Our work suggests that vigorous physical activity or brisk walking can have a benefit at the earlier stages of the disease,” said Chan, the Steven and Christine Burd-Safeway Distinguished Professor at UCSF and senior author of both studies.
After skin cancer, prostate cancer is the most commonly diagnosed type of cancer among men in the United States, and more than 217,000 U.S. men are diagnosed with the disease every year according to the National Cancer Institute. Last year alone 32,050 men died from the disease.
Vigorous exercise and brisk walking consistently have been shown to have significant benefits on cardiovascular health, diabetes and many other diseases. Previous studies also have shown the benefit of regular physical activity for disease outcomes in breast and colon cancer, but this is one of the first studies to demonstrate such a benefit for men with prostate cancer.
The participants in this study were selected were a subset of a larger group of 14,000 men with prostate cancer who are enrolled in a long-term, nationwide prostate cancer registry study known as the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE), led by Dr. Peter Carroll, MPH, who is the chair of the Urology Department at UCSF and an author of the study.
A particular strength of this study is the focus on early recurrence of prostate cancer, which occurs before men may experience painful symptoms of prostate cancer metastases, a frequent cause for men to decrease their usual physical activity. Additionally, the researchers reported that the benefit of physical activity was independent of the participants’ age at diagnosis, type of treatment and clinical features of their disease at diagnosis.
Asked whether she would recommend walking for all men who are diagnosed with prostate cancer, Dr. Chan said yes — but emphasized that the walking must be brisk.
“Our results suggest that it is important to engage in exercise that gets your heart rate up a little bit,” she advised.
The article, “Physical activity after diagnosis and risk of prostate cancer progression: data from the Cancer of the Prostate Strategic Urologic Research Endeavor” is authored by Erin L. Richman, Stacey A. Kenfield, Meir J. Stampfer, Alan Paciorek, Peter R. Carroll and June M. Chan.
This work was funded by the Department of Defense, the Prostate Cancer Foundation, Abbott Labs and through a National Institutes of Health training grant.
UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. Follow UCSF on Twitter.
Data from: universityofcalifornia.edu
24 May 2011 Last updated at 16:07 GMT
Brisk walks fight prostate cancer
By Michelle RobertsHealth reporter, BBC News
Men who have been recently diagnosed with prostate cancer can help keep their disease at bay by taking brisk walks, claim researchers.
Based on their observations, men who power walk for at least three hours a week can halve how much their cancer will grow and spread over the next couple of years.
Strolling does not have the same effect, Cancer Research journal warns.
Experts say it shows that keeping active can improve health.
But they say the findings should be interpreted with caution because the men who did more walking also tended to be younger, leaner, and non-smokers, which could also explain some of the differences seen.
The University of California San Francisco study looked at the outcomes of 1,455 men, mostly in their 60s, who were diagnosed with “localised” prostate cancer, meaning it had not yet started to spread.
The men were asked to say how much exercise and of what type they took in the average week.
During the 31 months of follow up, the US researchers recorded 117 events, including disease recurrence, bone tumours and deaths specifically caused by prostate cancer.
And they found that men who walked briskly for at least three hours a week were far less likely to have one of these events.
The brisk walkers had a 57% rate of progression of disease than men who walked at an easy pace for less than three hours a week.
Lead researcher Erin Richman said: “It appears that men who walk briskly after their diagnosis may delay or even prevent progression of their disease.
“The benefit from walking truly depended on how quickly you walked. Walking at an easy pace did not seem to have any benefit.
“Walking is something everyone can and should do to improve their health.”
The scientists believe power walking might affect prostate cancer progression by changing blood levels of certain proteins that have been shown in the lab to encourage cancer growth.
Dr Helen Rippon, head of research management at The Prostate Cancer Charity, said: “Although this research will need to be repeated to make sure the results can be applied to all men with prostate cancer, we would certainly advise men diagnosed with prostate cancer to ensure that their lifestyle includes a good amount of physical activity – and walking is often the easiest way of achieving this.”
Liz Woolf of Cancer Research UK said: “We know there are many benefits to exercise and that it can help people to recover more quickly after cancer treatment but it’s difficult to set specific levels of exercise as everyone’s needs and abilities are different.
“Just to be safe, it is important that people with cancer check with their doctor before taking up any new form of exercise.”
Data from: bbc.co.uk