New solution: A sugar solution injected into the knee may be a new method of treating osteo-arthritis

New solution: A sugar solution injected into the knee may be a new method of treating osteo-arthritis


  • การบำบัดแบบ Prolotherapy เกี่ยวข้องกับการฉีดสารละลายน้ำตาลที่หัวเข่า
  • การกระตุ้นนี้ปล่อยเซลล์ที่สามารถช่วยให้เกิดกระบวนการเยียวยาข้อเสื่อม

การใช้สารละลายน้ำตาลเดกซ์โทรส 10 -25 % ฉีดเข้าไปในข้อเข่าอาจเป็นวิธีใหม่ในการรักษาโรคข้อเสื่อม โดยน้ำตาลและน้ำจะช่วยลดอาการปวดและตึงโดยการกระตุ้นกลไกการซ่อมแซมร่างกายตามธรรมชาติ


การอักเสบนี้ไม่เพียงพอที่จะก่อให้เกิดอันตรายใด ๆ ที่รุนแรง แต่เพียงจะกระตุ้นการปล่อยเซลล์ที่สามารถช่วยในการรักษาความเสียหายบางส่วนที่เกิดจากโรค




Sweet release: The treatment, known as prolotherapy, is thought to work by triggering the release of cells that repair damaged ligaments in the knee

Sweet release: The treatment, known as prolotherapy, is thought to work by triggering the release of cells that repair damaged ligaments in the knee

A dose of sugar can ease the pain of creaky knees by releasing cells that repair damaged ligaments

  • Prolotherapy involves injecting a sugar solution into the knee
  • This stimulates the release of cells that can help the healing process


PUBLISHED: 21:11 GMT, 8 July 2013

A sugar solution injected into the knee could be a new way to treat osteo-arthritis. Research suggests the sugar and water mixture reduces pain and stiffness by stimulating the body’s natural repair mechanisms.

The sweet solution works by acting as a mild irritant inside the joint, triggering low-level inflammation.

This inflammation is not enough to cause any severe harm, but is sufficient to stimulate the release of cells that can help to heal some of the damage caused by the disease.

Doctors use a solution containing water and between 10 and 25 per cent dextrose, a type of sugar.

They use dextrose because it is cheap, readily available and safe – causing only mild irritation inside the knee joint. The treatment, known as prolotherapy, is thought to work by triggering the release of fibroblasts, cells that build and maintain connective tissue such as ligaments.

The fibroblasts repair damaged ligaments in the knee, making it more stable and relieving discomfort.

In a recent study at the University of Wisconsin in the U.S., researchers recruited 90 men and women with painful knee osteoarthritis and split them into three groups.

One group received three separate sugar jabs, each one four weeks apart, and another had injections of a salt water solution.

The last group did not have any injections but instead followed an at-home exercise regimen designed to alleviate some of the pain and discomfort.

Each volunteer was monitored using a scoring  system, called the Western Ontario McMaster University Osteo-arthritis Index, to measure the severity of the condition. The 12-minute test uses a 100-point scale  and includes questions on how easy it is to use the stairs, get in and out of a car or put on a pair of socks.

The results, published in the Annals of Family Medicine, showed that one year after the treatment began, the sugar jab group had the biggest improvement in symptoms and were better able to carry out everyday activities.

On average, the sugar group improved by a total of 16 points, compared with five points for salt water jabs and seven for the exercise group. The team are unsure why salt water was not as effective as sugar.

This technique is also being tried in other conditions such as chronic back pain and tennis elbow.

Commenting on the approach, Professor Alan Silman, medical director of Arthritis Research UK, said: ‘Though some “irritant” treatments can be effective, much more work is needed before a treatment based on sugar solution could be recommended to patients.’

Meanwhile, scientists have designed a special glove that may ease the pain of hand arthritis.

Around 130 people who suffer from rheumatoid and osteoarthritis are being treated with the compression glove in a new clinical trial.

The gloves are made from a special fabric that when stretched (when it is worn) puts pressure on the hand and joints.

It’s thought that the pressure might trigger mild inflammation, which, unlike severe inflammation, eases pain although it is not clear why.

In the year-long trial, due to start in September and being  co-ordinated by the University of Salford, patients will be given the compression gloves as part of their usual care.

They will be assessed before and after for pain and stiffness.

SOURCE: www.dailymail.co.uk

การทำสมาธิสามารถบรรเทาอาการปวดที่เกี่ยวข้องจากความเครียดเช่นโรค IBS และโรคข้ออักเสบ

The study suggests gaining 'inner peace' can have a very real outward effect

The study suggests gaining ‘inner peace’ can have a very real outward effect

การทำสมาธิสามารถบรรเทาอาการปวดที่เกี่ยวข้องจากความเครียด เช่น โรคลำไส้แปรปรวน IBS และโรคข้ออักเสบ

Meditation can ease pain from stress-related conditions like IBS and arthritis

  • Mindfulness meditation involves ‘being present’ by focusing on the breath and bodily sensations
  • Study compared a group practising mindfulness with another using alternative relaxation methods
  • Only mindfulness reduced inflammation caused by an irritating cream


PUBLISHED: 16:01 GMT, 17 January 2013

People who suffer from painful conditions such as rheumatoid arthritis could ease their symptoms using a form of meditation, say researchers.

They added that the treatment, known as mindfulness, could prove a cheaper alternative to prescription medicines.

Mindfulness meditation involves ‘being present’ by focusing on breathing patterns and bodily sensations. This reduces worrying about the past and future and has been shown to be effective at alleviating depression.

The latest study suggested its calming effect could help those with stress-related chronic inflammatory conditions – such as bowel disease and asthma.

It is also a convenient technique as people can do the meditation exercises while sitting down or walking, according to the authors from the University of Wisconsin.

It comes as family doctors in the UK are being told to slash prescriptions of painkillers and sleeping pills amid concerns that patients are becoming addicted.

New guidelines now urge doctors  to consider alternative treatments such as physiotherapy and counselling.

Study leader Melissa Rosenkranz, said some people don’t benefit from regular medicines with many suffering from negative side effects of drugs or failing to respond to standard treatment.

Ms Rosenkranz said: ‘Our study shows that there are specific ways mindfulness (meditation) can be beneficial and that there are specific people who may be more likely to benefit from this approach than other interventions.

‘The mindfulness-based approach to stress reduction may offer a lower-cost alternative or complement standard treatment and it can be practised easily by patients in their own homes, whenever they need.’

The study compared two different methods of reducing stress, one related to meditation and the other involving exercise and musical therapy.

The content of the program was meant to match aspects of the mindfulness instruction in some way. For example, physical exercise was meant to match walking meditation, without the mindfulness component.

‘In this setting, we could see if there were changes that we could detect that were specific to mindfulness,’ Rosenkranz said.

Cream containing heat from chilli peppers was used to inflame the skin of participants in both groups. Although both groups felt calmer after therapy, only mindfulness proved effective at reducing the inflammation.

Ms Rosenkranz added: ‘The study suggests that mindfulness techniques may be more effective in relieving inflammatory symptoms than other activities that promote well-being.

‘This is not a cure-all, but our study does show that – there are specific people who may be more likely to benefit from this approach than other interventions.’

Significant portions of the population do not benefit from available pharmaceutical treatment options. Some of these patients suffer from negative side effects of the drugs, or simply do not respond to the standard-of-care for treatment of the disorder.

More information about mindfulness can be found at http://www.bemindful.co.uk/

SOURCE: dailymail.co.uk

Immunologists find a molecule that puts the brakes on inflammation

Christopher Hunter and Aisling O’Hara Hall

(Medical Xpress) September 28, 2012—We couldn’t live without our immune systems, always tuned to detect and eradicate invading pathogens and particles. But sometimes the immune response goes overboard, triggering autoimmune diseases like lupus, asthma or inflammatory bowel disease.

A new study led by University of Pennsylvania researchers has now identified a crucial signaling molecule involved in counterbalancing the immune system attack.

“The immune response is like driving a car,” said Christopher Hunter, professor and chair in the Department of Pathobiology in Penn’s School of Veterinary Medicine. “You hit the accelerator and develop this response that’s required to protect you from a pathogen, but, unless you have a brake to guide the response, then you’ll just careen off the road and die because you can’t control the speed of the response.”

The research to characterize this immune system “brake” was led by Hunter and Aisling O’Hara Hall, a doctoral candidate in the Immunology Graduate Group. Additional Penn collaborators included scientists from the Penn Genome Frontiers Institute’s Department of Biology and the Perelman School of Medicine’s Department of Medicine.Researchers from Merck Research Laboratories, the National Institute of Allergy and Infectious Disease, Harvard Medical School and Janssen Research and Development also contributed to the work, which was published in the journal Immunity.

“Healthy people have these cells—you have them, I have them—that are called Tregs,” or regulatory T cells, Hunter said. “If you don’t have them you develop spontaneous inflammation and disease.”

Different forms of regulatory T cells operate as the brakes on various kinds of inflammation, but, until now, scientists hadn’t been certain of how these Tregs became specialized to do their particular jobs.

Hall, Hunter and colleagues decided to follow up on a molecule called IL-27. Scientists used to think IL-27 played a role in causing inflammation, but, in 2005, a team of Penn researchers, including Hunter, found the opposite; it was actually involved in suppressing inflammation. Thus, when mice that lack IL-27 are challenged with the parasite Toxoplasma gondii, they develop overwhelming inflammation. ”

We never worked out how it did that, but it was a paradigm change at the time,” Hunter said.

In the new study, the researchers delved deeper into IL-27’s role. They found that exposing regulatory T cells to IL-27 promoted their ability to suppress a particular type of inflammation. The Penn-led team also demonstrated that they could rescue infected IL-27-deficient mice by giving them a transfusion of regulatory T cells. This finding suggests that IL-27 is required to produce the Treg cells that normally keep inflammatory responses in check during infection.

“Very surprisingly, we were able to show that the Tregs could ameliorate the pathology in this system,” Hall said. “We don’t think this is the only mechanism by which IL-27 limits immune pathology, but it sheds light on one mechanism by which it could be functioning.”

Further experiments showed that Tregs express a different suite of genes in the presence of IL-27 as compared to another molecule that has been implicated in this process, interferon gamma, or IFN-γ. The researchers’ findings indicate that the two molecules have division of labor when it comes to suppressing inflammation: IL-27 seems to be important in helping control inflammation at the site of inflammation, whereas IFN-γ appears more significant in the peripheral tissues.

“At the site of inflammation, where you’re getting your pathology, that’s where IL- 27 is important,” Hall said.

With a new understanding of how IL-27 may cause a class of Tregs to become specialized inflammation fighters, researchers have a new target for ameliorating the unwanted inflammation associated with all kinds of autoimmune conditions.

“Now we have a molecular signature that may be relevant in inflammatory bowel disease, in multiple sclerosis, in colitis and Crohn’s disease, in rheumatoid arthritis, in lupus,” Hunter said.

Next on tap, the team plans to study IL-27 in the context of asthma , lupus and arthritis.

More information: dx.doi.org/10.1016… .2012.06.014 J
Journal reference: Immunity
Provided by University of Pennsylvania

SOURCE: medicalxpress.com