การรับประทานน้ำมันปลาและแอสไพรินร่วมกันจะช่วยบรรเทาความเจ็บป่วยเรื้อรัง เช่น โรคข้อ

Scientists have discovered that taking fish oil and aspirin together could help to ease beat chronic illnesses such as arthritis

Scientists have discovered that taking fish oil and aspirin together could help to ease beat chronic illnesses such as arthritis


นักวิทยาศาสตร์พบว่าการรับประทานน้ำมันปลาและแอสไพรินร่วมกันจะช่วยบรรเทาความเจ็บป่วยเรื้อรัง เช่น โรคข้ออักเสบ


Fish oils have long been heralded for their beneficial effects on the brain, bones and heart

Fish oils have long been heralded for their beneficial effects on the brain, bones and heart

The cure for arthritis? Fish oil AND aspirin, according to a breakthrough discovery

  • The two work together to combat inflammation that causes pain of arthritis


PUBLISHED: 18:17 GMT, 22 February 2013

Fish oil and aspirin could be the key to beating a host of devastating chronic diseases, according to new research.

Researchers from the Brigham and Women’s Hospital and Harvard Medical School in Boston found that the two work together to combat the inflammation responsible for a host of illnesses, including heart disease, cancer, arthritis and Alzheimer’s.

Both aspirin and omega-3 fatty acids from fish are known to have an anti-inflammatory effect on their own, but the research shows that when taken together they can control the overactive immune responses associated with long-term illnesses.

Inflammation is the body’s natural response to injury and foreign bodies.

When something harmful or irritating affects a part of the body, there is a biological response to try to remove it, and the symptoms of inflammation show that the body is trying to heal itself.

But if the person suffering has a high-fat diet, too much body fat or is a smoker, for example, the may not be a break from the irritants, so the immune system can lose control, increasing risk of disease.

Long-term, inflammation can become chronic which can then damage heart valves and brain cells, causing strokes and promoting resistance to insulin, which leads to diabetes.

It is also associated with the development of cancer.

Aspirin is used by millions of people to keep heart attacks and strokes at bay. The drug is used to thin the blood, which reduces the risk of clots.

It works by helping to trigger the production of molecules called resolvins that are made naturally by the body from omega-3 fatty acids.

These resolvins ‘resolve’, the inflammation that underlies the health conditions which blight the lives of millions.

Omega-3 is found in oily fish, particularly salmon and sardines, as well as chicken, nuts, kale and spinach as well as vegetable oils.

One resolvin called D3 was found to have an especially long-lasting anti-inflammatory effect.

The researchers said: ‘In this report, we found that one resolvin, termed D3 and from omega-3 fatty acid, persists longer at sites of inflammation than either resolvin D1 or resolvin D2 in the nat­ural resolution of inflammation in mice.

‘This finding suggests that this late resolution phase resolvin D3 might display unique properties in fighting uncontrolled inflammation.’

The researchers also confirmed that aspirin triggered the production of a longer-acting form of resolvin D3 through a different pathway.

The team were able to produce a pure form of both resolvin D3 and aspirin-triggered resolvin D3.

When administered to human cells, both of these showed highly potent anti-inflammatory actions.

The research was published in the journal Chemistry & Biology.

SOURCE: dailymail.co.uk

ผู้สููงอายุจะเดินเหินให้คล่องแคล่วขึ้น โด๊ปด้วยกรดไขมันร่วมกับออกกำลัง

ผู้สูงอายุที่เคลื่อนไหวได้อย่างจำกัด ถ้าหากพยายามออกกำลังขนาดปานกลางและกินกรดไขมันปลาประจำจะช่วยให้เคลื่อนไหวได้ดีขึ้น

นักวิจัยมหาวิทยาลัยอเบอร์ดีนได้ทดสอบกับผู้หญิงสูงอายุ วัยเกิน 65 ปีขึ้นไปให้กินกรดไขมันโอเมกา-3 ทำให้กล้ามเนื้อแข็งแรงกลับขึ้นอีกเกือบเท่าตัว สร้างความฉงนจนเตรียมจะทำการทดสอบขนาดใหญ่ขึ้นใหม่ เพื่อจะได้ทราบว่าเหตุใดกล้ามเนื้อถึงได้แข็งแรงขึ้นได้แน่ๆ

ในการศึกษาที่แล้วมาบางเรื่องได้พบว่ากรดโอเมกา-3 มีส่วนเกี่ยวพันกับการส่งเสริมสุขภาพ อย่างเช่นทำให้ความเสี่ยงกับโรคหลอดเลือดหัวใจลดลง

โดยธรรมชาติแล้ว ความแข็งแรงของกล้ามเนื้อของผู้สูงอายุที่แข็งแรงดี จะลดลงปีละระหว่างร้อยละ 0.5-2 ทำให้เกิดผอมแห้งแรงน้อยและเคลื่อนไหวได้จำกัดลง.

ที่มา: ไทยรัฐ 14 กันยายน 2555


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Fish oils ‘help slow age decline’

By Jonathan Ball
BBC News, Aberdeen

Moderate exercise, and a regular intake of oily fish fatty acids, keeps elderly immobility at bay, a study suggests.

Findings of a recent trial show that women aged over 65 who received omega-3 fatty acids gained almost twice as much muscle strength following exercise than those taking olive oil.

A larger trial is planned to confirm these findings and to determine why muscle condition improves.

The findings are being presented at the British Science Festival in Aberdeen.

Some studies have linked diets high in omega-3 – commonly found in oily fish such as mackerel and sardines – to potential health benefits, such as a lower risk of coronary heart disease.

During healthy ageing, muscle size is reduced by 0.5-2% per year.

This process – known as sarcopenia – can result in frailty and immobility in old people.

Little is known about the prevalence of sarcopenia in the UK, but data from the US shows that 25% of people aged 50-70 have sarcopenia and this increases to more than half of those aged over 80 years.

According to Dr Stuart Gray from the University of Aberdeen, the cost of sarcopenia is immense; either in direct nursing and care costs or in hospital admissions through falls.

“Around one-and-a-half percent of the total US healthcare budget is spent on sarcopenia-related issues”, he said.

Tales from the farmyard

The rate of muscle loss is dictated to some extent by lifestyle – consumption of a low protein diet and a sedentary lifestyle are known to exacerbate muscle loss.

Previous studies demonstrated that livestock fed on omega 3-rich diets had increased muscle bulk.

This prompted Dr Gray to investigate whether these fatty acids could help reverse sarcopenia in the elderly.

In his initial studies, he showed by MRI imaging that middle-aged rats taking fish oil supplement had a lower loss of lean mass than counterparts fed a normal diet.

“The fish oil seemed to be having anabolic [muscle-building] protective effects in the rats, but rats aren’t humans, so the next step was to try it in humans,” he said.

So, Dr Gray recruited 14 women aged over 65 years and asked both groups to undergo a 12 week exercise programme consisting of two 30-minute sessions of standard leg muscle exercises.

Half the women were given the omega-3 fatty acids EPA and DHA, whist the other half received an olive oil placebo (negative control).

At the start and end of the trial, the women’s leg muscle strength was measured.

The results were compelling. Women receiving olive oil increased their muscle mass by 11% whilst those receiving EPA and DHA showed a 20% increase – a statistically significant improvement.

But as Dr Gray was quick to point out, not all fish oil supplements contain beneficial amounts of these fatty acids. He told BBC News:

“One of the problems with a lot of these supplements is that the amount of EPA varies.

“A capsule containing one gram of fish oil might only contain 100 milligrams (mg) of EPA and some might contain 400”.

His advice for anyone wanting to improve their intake of dietary EPA and DHA was to take a supplement that contained the highest levels of these two fatty acids.

Alternatively, half of the average portion of oily fish contains equivalent amounts of beneficial EPA and DHA as those used in the trial.

Sex difference

The researchers have now received funding to carry out a larger trial that includes 60 people aged over 65 years to confirm the beneficial effects of the fatty acids. The new trial will recruit similar numbers of men and women.

Previous research has shown that men and women differ in their ability to synthesise new protein and also in their response to exercise.

“Older women have similar levels of protein synthesis to younger women whereas older men have lower levels compared to younger men.”

“Older men adapt to exercise and increase their protein synthesis. Older women don’t do this to a great extent, although their basal levels of synthesis are higher,” Dr Gray explained.

Assessing whether women and men respond differently to exercise and fatty acid supplements will be one of the questions that the new trial will address.

The trial is scheduled to start in the next month and will recruit people from the Aberdeenshire area.


SOURCE: bbc.co.uk