อานุภาพของวัคซีนโรคไข้หวัดใหญ่ช่วยคุ้มหัวใจวาย-โรคลมอัมพาต

นักวิจัยแคนาดาค้นคว้าทบทวนผลการศึกษาเรื่องต่างๆ พบว่าการฉีดวัคซีนป้องกันโรคไข้หวัดใหญ่ไม่เพียงแต่จะป้องกันโรคหวัดเท่านั้น หากเทียบกับผู้ที่ไม่ได้ฉีด มันยังมีฤทธิ์ป้องกันโรคหัวใจวายหรือลมอัมพาตได้ตั้งครึ่งต่อครึ่ง หรือตายด้วยโรคเหล่านี้น้อยลงไปถึงร้อยละ 40

ดร.จาคอป อูเดลล์ แพทย์โรคหัวใจของโรงพยาบาลวิทยาลัยสตรี และมหาวิทยาลัยโตรอนโตกับคณะ ผู้ซึ่งศึกษาทบทวน กล่าวว่า วัคซีนโรคหวัด อาจเป็นวิธีการสำคัญของการบำรุงสุขภาพหัวใจ และป้องกันโรคหัวใจวายกับโรคลมอัมพาตที่สำคัญอย่างหนึ่ง “ผลการค้นพบ บางทีอาจส่อว่าวัคซีนป้องกันโรคหวัดก็คือวัคซีนป้องกันโรคหัวใจด้วย”

หมออูเดลล์ยอมรับว่า ยังไม่รู้สาเหตุที่วัคซีนมีสรรพคุณป้องกันโรคหัวใจได้ อาจเป็นเพราะวัคซีนได้กำจัดคราบที่จับอยู่ในหลอดเลือด ในขณะที่ ดร.ซาราห์ สมามาน แพทย์ผู้เชี่ยวชาญ มีความเห็นว่า สิ่งสำคัญอยู่ที่การช่วยลดการอักเสบ เมื่อคนเราเป็นหวัด ในเลือดจะมีตัวก่อการอักเสบสูงขึ้น ซึ่งการอักเสบในหลอดเลือด อาจเป็นเหตุให้หัวใจวายได้.

ที่มา: ไทยรัฐ 2 พฤศจิกายน 2555

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Influenza Vaccine May Reduce Risk of Heart Disease and Death: Flu Shot May Reduce Risk of Major Cardiac Event by 50 Percent

ScienceDaily (Oct. 28, 2012) — Getting a flu shot may not only protect you from getting sick, it might also prevent heart disease. Two Toronto-based researchers presented studies at the 2012 Canadian Cardiovascular Congress which found that the influenza vaccine could be an important treatment for maintaining heart health and warding off cardiovascular events like strokes and heart attacks.

Dr. Jacob Udell, a cardiologist at Women’s College Hospital and the University of Toronto, and his team from the TIMI Study Group and Network for Innovation in Clinical Research looked at published clinical trials on this subject, dating back to the 1960s.

“For those who had the flu shot, there was a pretty strong risk reduction,” says Dr. Udell.

The flu vaccine provided an approximate 50 per cent reduction in the risk of a major cardiac event (heart attack, stroke, or cardiac death) compared with placebo after one year of follow-up. A similar trend was seen for the flu vaccine reducing death from any cause (approximately 40 per cent).

The influenza vaccine reduced cardiovascular events and cardiovascular death in people with or without heart disease.

The combined studies examined a total of 3,227 patients, with an almost equal split between patients with and without established heart disease. Half of the participants were randomly assigned to receive flu vaccine and those that did not typically received a placebo vaccine.

Dr. Udell says these results provide support for current guideline recommendations for influenza vaccination of individuals with a prior heart attack, but for a different reason than simply reducing flu risk. And although it was encouraging to see a reduction in non-fatal cardiac events, he believes a large, lengthier multi-national study would comprehensively demonstrate the vaccine’s effectiveness to reduce fatal cardiac events and save lives.

“A large study that was international in scope and representative of patients such as those in North America and Canada in particular could help answer this question,” he says.

This research could also potentially boost use of the vaccine, which Udell believes is still woefully low. “The use of the vaccine is still much too low, less than 50 per cent of the general population; it’s even poorly used among health care workers,” he says. “Imagine if this vaccine could also be a proven way to prevent heart disease.”

An Ipsos Reid survey conducted by B.C. and Quebec Lung Associations this year found that 36 per cent of Canadians reported having received a flu shot in 2011.

And according to the Public Health Agency of Canada’s National Advisory Committee on Immunization (NACI), the 2008 Adult National Immunization Coverage Survey found that vaccination rates for adults 18 to 64 years of age with a chronic medical condition is low at 35 per cent.

It also found that non-institutionalized seniors aged 65 and older have higher coverage, at 66 per cent.

According to the NACI, rates for both groups have declined somewhat since their 2006 survey and fall short of the 80 per cent national targets for influenza vaccine coverage in adults under age 65 with chronic conditions and in seniors.

People with ICDS who get the shot have fewer adverse events The second study, conducted by cardiologists Drs. Ramanan Kumareswaran and Sheldon Singh from Sunnybrook Health Sciences Centre examined the use of the influenza vaccine in patients with implantable cardiac defibrillators or ICDs.

“Anecdotes suggest that patients have more ICD shocks during flu season. We were trying to figure out what we can do to reduce the amount of shocks in (our clinic’s) ICD population during the flu season,” says Dr. Kumareswaran.

Patients with ICDs that had appointments at the Sunnybrook Hospital ICD clinic between September 1st 2011 and November 31st 2011 completed a survey that identified their demographics, health status, if they received a flu shot in the past year and opinions towards the vaccine.

The patients’ health charts were reviewed to determine all ICD therapies in five months preceding the 2010 flu season (June to October) and for three months during the 2010-2011 flu season (December to March).

A total of 230 patients with an average age between 70 and 74 completed surveys with 179 (78 per cent) patients reported receiving the vaccination in the previous year. Just over 20 per cent did not receive the vaccine.

The patients who did not receive the flu vaccine had a trend toward experiencing more ICD therapies on average. Specifically, 10.6 per cent of patients who received the vaccine received at least one ICD therapy during flu season compared to 13.7 per cent of patients who did not receive the influenza vaccine.

“What is interesting is that if this is consistent over time, it could be of significant benefit to our patient population who already have compromised survival to start with,” says Dr. Singh.

“We would like to look at this on a larger scale to determine whether or not our results can be replicated. We’re in the process to determine how best to do that.” An ICD is a small battery-powered electrical impulse generator implanted in patients who are at risk of sudden cardiac death.

The device is programmed to detect cardiac arrhythmia and correct it by delivering a jolt of electricity or increasing the heart rate to restore a healthy rhythm once an irregular beat has been detected.

About 5,000 Canadians get ICDs every year and there are about 100,000 Canadians who currently have them. (Most Canadians with advanced heart disease are potential candidates for ICDs.)

Heart and Stroke Foundation spokesperson Dr. Beth Abramson says these studies strengthen National Advisory Committee for Immunization recommendations for the use of the influenza vaccine in those at high risk of developing influenza related complications, such as patients with heart disease or diabetes, and those who have close contact with those at high risk of developing complications.

“In addition to leading a heart healthy life, having an annual flu shot could be another easy way to help prevent cardiac events,” she says.

Dr. Abramson notes that the Heart and Stroke Foundation recommends an influenza vaccination for those at high risk of influenza-related complications or hospitalization (including people with heart conditions, those with diabetes, people over 65 years of age, people with a BMI at or above 40 and children or adults treated with ASA). It is also recommended for people who are most likely to transmit influenza to high risk individuals (family members, friends, coworkers, healthcare provider and caregivers).

Story Source:

The above story is reprinted from materials provided byHeart and Stroke Foundation of Canada, via EurekAlert!, a service of AAAS.

SOURCE: sciencedaily.com

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กินแตงโมช่วยป้องกันโรคหัวใจได้ แค่เพียงชิ้นบาง ๆ วันละชิ้น

นักวิจัยมหาวิทยาลัยเปอร์ดิวของสหรัฐฯ พบว่า การกินแตงโมวันละหนึ่งชิ้นบางๆ จะช่วยป้องกันโรคหัวใจ และน้ำหนักเกินได้ เพราะมันจะช่วยป้องกันการสะสมของไขมันที่เป็นอันตราย

นักวิจัยได้ศึกษากับหนูทดลองที่ถูกขุนให้กินอาหารไขมันสูง ได้ความรู้ว่า การกินแตงโมจะช่วยลดอัตราสะสมของไขมันรวมโปรตีนเลว ที่มีความหนาแน่นต่ำลงเกือบครึ่ง ไขมันเลวทำให้หลอดเลือดอุดตัน และเป็นโรคหัวใจ

ขณะที่แตงโมช่วยควบคุมน้ำหนักตัวไม่ให้เพิ่มขึ้น และลดปริมาณไขมันที่จับอยู่ภายในหลอดเลือด และคิดว่าคุณประโยชน์ของแตงโมอาจจะเป็นเพราะสารไซตรุลไลน์ อันเป็นสารเคมีที่พบอยู่ในน้ำคั้นของมัน สารนี้เป็นกรดอะมิโนชนิดหนึ่ง เกี่ยวกับการสร้างยูเรียในร่างกาย เคยมีการศึกษาพบว่ามันมีสรรพคุณป้องกันโรคหัวใจ โดยช่วยลดความดันโลหิตลงได้.

ที่มา: ไทยรัฐ 9 ตุลาคม 2555

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Could watermelon the key to lowering cholesterol?

How watermelon could prevent heart attacks AND weight gain  

  • Daily slice could halve the build-up of ‘bad’ cholesterol
  • It could also help prevent weight gain

By PAT HAGAN

PUBLISHED: 10:05 GMT, 4 October 2012

A daily slice of watermelon could help prevent heart disease by halting the build-up of harmful cholesterol, new research shows.

Scientists who carried out studies on mice fed a high-fat diet found the fruit halved the rate at which ‘bad’ low-density lipoprotein, or LDL, accumulated.

LDL is a form of cholesterol that leads to clogged arteries and heart disease.

Researchers from Purdue University in the US also found eating watermelon regularly helped to control weight gain and resulted in fewer fatty deposits inside blood vessels.

They believe the secret to watermelon’s health-boosting properties lies in citrulline, a chemical found in the juice.

Previous studies have suggested citrulline has a role to play in heart disease prevention by lowering blood pressure.

Although the latest investigation showed no significant effects on blood pressure, it did reveal watermelons had a powerful impact on other heart risk factors.

Heart disease is Britain’s biggest killer. Around 270,000 people a year suffer a heart attack and nearly one in three die before they reach hospital.

Fatty diets, lack of exercise and smoking are all key risk factors.

Cholesterol is a type of fat produced by the liver that is essential to help the body produce hormones, absorb vitamin D and make bile to digest foods.

It is transported in the blood by tiny ‘couriers’, called lipoproteins.

LDL carries cholesterol away from the liver and dumps it in major blood vessels, where it can cause a life-threatening blockage.

High-density lipoprotein, or HDL, has the job of transporting cholesterol back to the liver to be safely disposed of.

Current guidelines in the UK recommend keeping total cholesterol below 5mmols per litre, a measurement of how much fat there is in each litre of blood in the body, with LDL accounting for no more than 3mmols/litre.

But an estimated 20 per cent of patients with excessive LDL levels are classed as resistant to statins – the drugs taken by around seven million people in the UK to control cholesterol.

Cholesterol causes the arteries to narrow, raising the risk of heart attack and stroke

The latest study, published in the Journal of Nutritional Biochemistry, suggests watermelon juice could help.

Researchers fed two groups of mice a high-fat diet but gave one water to drink and the other watermelon juice.

They tracked their health for several months and at the end of the experiment found the mice given watermelon juice had 50 per cent less LDL than those on water – despite eating the same diet.

They also weighed an average of 30 per cent less, but their blood pressure was no different.

Research leader Dr Shubin Saha said: ‘We didn’t see a lowering of blood pressure. But these other changes are promising.

‘We know that watermelon is good for health because it contains citrulline. We don’t know yet at what molecular level it’s working and that’s the next step.’

Some studies suggest the chemical is vital for the production of nitric oxide, a gas that widens blood vessels.

This research follows another recent study published in the Journal of Functional Foods which suggested eating apples each day could significantly improve the heart health of middle-aged adults in just one month.

Those who ate a daily apple over four weeks lowered ‘bad’ cholesterol in the blood by 40 per cent.

Taking capsules containing polyphenols, a type of antioxidant found in apples, had a similar, but not as large, effect.

Bad cholesterol can interact with free radicals to become oxidized, which can trigger inflammation and can cause tissue damage.

SOURCE: dailymail.co.uk

แอสไพรินช่วยถ่วงอาการโรคสมองเสื่อมให้ผู้สูงอายุที่เป็นโรคหัวใจหลอดเลือด

แพทย์สวีเดนศึกษาพบว่า กินแอสไพรินวันละเม็ด จะช่วยผู้สูงอายุที่ล่อแหลมจะเป็นโรคหัวใจและหลอดเลือดสูง ห่างจากโรคสมองเสื่อมได้

หมอสวีเดนได้ศึกษาจากกลุ่มสตรีสูงอายุ วัยระหว่าง 70-92 ปี ประมาณ 500 คน ด้วยการทดสอบทางสติปัญญา มาเป็นเวลานาน 5 ปี พบว่า คนที่ไม่ได้กินยาแอสไพริน จะทำคะแนนได้น้อยกว่า ผู้ที่กินยาแอสไพรินมาตลอดเวลา

วารสารวิชาการ “การแพทย์อังกฤษ” รายงานผลการศึกษาว่า นักวิจัยพบว่า แม้แอสไพรินจะช่วยชะลอผู้ล่อแหลมกับโรคหัวใจวายหรือลมอัมพาต จากโรคสติปัญญาเสื่อมได้ แต่ก็ไม่ได้ทำให้อัตราการป่วยด้วยโรคสมองเสื่อมในหมู่สตรีเกิดขึ้นช้าหรือเร็วได้

ดร.ซิลค์ เคม หัวหน้านักวิจัย กล่าวว่า “เรายังไม่ทราบความเสี่ยงของการกินแอสไพรินเป็นเวลานาน อย่างเช่น การเป็นแผลในกระเพาะและการตกเลือดว่า จะมากน้อยเพียงไร จึงต้องศึกษากันต่อไปอีก อาจจะต้องคอยติดตามศึกษาสตรีกลุ่มนี้ต่อไปอีก 5 ปี”.

ที่มา: ไทยรัฐ 8 ตุลาคม 2555

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Older women who took low doses of aspirin found it helped to preserve their memory

Taking low dose of aspirin to prevent heart disease could slow down memory loss 

  • Older women taking low doses to prevent heart disease found it helped to preserve memory

By JENNY HOPE

PUBLISHED: 17:30 GMT, 3 October 2012

Taking a low dose of aspirin may help keep the brain young, claim researchers.

A study of older women taking low doses to prevent heart disease found it also helped preserve their memory.

Millions of Britons take aspirin on doctor’s orders to prevent heart problems.

Other research suggests it may cut the risk of cancer.

There have been conflicting results from studies about whether long-term use of Non Steroidal Anti Inflammatory drugs (NSAIDs) such as aspirin protects against declining brain power and dementia.

But research published in the online journal BMJ Open found regular low-dose aspirin did slow cognitive decline.

The five-year study at the University of Gothenburg, Sweden, involved 681 women aged 70 to 92.

The majority of women were at high risk of heart disease and stroke.

Decline in brain power was found to be considerably less among those who took aspirin every day over the entire period.

It is thought the same effect would be found in men.

 

All the elderly women were put through tests to measure their physical health and intellectual capacity, including verbal fluency and memory speed, and dementia.

A group of 129 women were taking low dose aspirin (75 to 160 mg) every day to ward off a heart attack or stroke when the study started. A further 94 were taking various other non-steroidal anti-inflammatory drugs (NSAIDs).

Their health was tracked over five years, at the end of which the intellectual capacity of 489 women was assessed again.

The mini-mental state examination (MMSE) score fell, on average, across the whole group at the end of the five years, but this decline was considerably less in the 66 women who had taken aspirin every day over the entire period.

The researchers then divided up the group into those who had taken aspirin for the entire five years (66); those who had stopped taking it by 2005-6 (18); those who were taking it by 2005-6 (67); and those who hadn’t taken the drug at any point (338).

Compared with women who had not taken aspirin at all, those who had done so for all five years, increased their MMSE score, while those who had taken aspirin at some point, registered only insignificant falls in MMSE score.

There were no differences, however, in the rate at which the women developed dementia.

 

The scientists say aspirin’s protective effect may be due to its anti-clotting action helping to improve blood flow to the brain.

Professor Clive Ballard, of the Alzheimer’s Society, said: ‘It is a potential additional benefit.  However aspirin does have a number of potentially serious side-effects with long-term use and shouldn’t be taken for long periods unless prescribed by a doctor.’

The author of the research paper, which was published in the online journal BMJ Open, expressed caution over the observational study as the MMSE can detect subtle changes in cognitive ability.

Dr Anne-Borjesson-Hanson University of Gothenburg in Sweden, said: ‘The findings indicate that aspirin may protect the brain, at least in women at high risk of a heart attack or stroke.’

SOURCE: dailymail.co.uk