Vitamin D may not relieve arthritis pain

Credit : phimaimedicine.org

Credit : phimaimedicine.org

วิตามินดี อาจจะไม่ช่วยบรรเทาปวดจากข้ออักเสบ

การศึกษาในสหรัฐอเมริกาพบว่า การกินวิตามินดีทุกวัน ไม่ได้ช่วยให้หายปวดเข่าหรือช่วยชะลอการสึกของผิวกระดูกอ่อนในข้อของผู้ป่วยข้อเสื่อม

Vitamin D may not relieve arthritis pain

Tue Jan 8, 2013 9:43pm EST
(Reuters) – Taking daily vitamin D doesn’t keep knee pain from getting worse or slow the loss of cartilage for people with osteoarthritis, according to a U.S. study.

Previous research suggested that among people with the joint disorder, those with higher levels of vitamin D in their blood tended to have a slower progression of symptoms. But whether that meant taking more in supplement form would also have a protective effect was unclear.

“It looked compelling at that point,” said lead author Timothy McAlindon, from Tufts Medical Center in Boston.

For the new study, published in the Journal of the American Medical Association, he and his colleagues randomly assigned 156 of their patients with knee osteoarthritis to take a daily dose of vitamin D or a vitamin-free placebo for two years.

None of the participants knew which type of supplement they were assigned to take. The vitamin D doses started at 2,000 international units (IU) per day and were increased to as high as 8,000 IU daily in some patients. For most adults, the recommended daily allowance of vitamin D is 600 to 800 IU.

The vitamin D group started out slightly worse off than their comparisons on measures of knee pain and function, but the vitamin didn’t seem to offer clear relief.

On a 0-to-20 point pain scale, people taking vitamin D saw a 2.3-point decrease during the two years, compared to a 1.5-point decrease among those taking placebos – a difference that could have been due to chance.

Changes in knee cartilage volume – a measure of the progression of osteoarthritis – and knee function were also similar among the two groups during and after the study period.

Robert Heaney, who has studied vitamin D at Creighton University School of Medicine in Omaha, Nebraska, said he wasn’t surprised the study didn’t find a beneficial effect on knee pain across all patients.

“It’s almost certain that vitamin D’s effects are different from person to person,” said Heaney, who wasn’t involved in the new research, to Reuters Health. “It’s very important for some people, but may not make any difference for others.”

That may have to do with genetics or other factors that doctors aren’t yet able to test for before the prescribe vitamin D, Heaney said, though he noted that it’s still worth trying since it may have other small health benefits.

McAlindon, however, disagreed, saying that while it’s possible the higher levels of vitamin D in the blood could help knee pain, so far the results don’t support that idea.

“Vitamin D broadly is the vitamin of the moment,” McAlindon said. “There are hopes that it will have wide health benefits.”

But he noted that this study shows each of those claims needs to be checked out carefully. SOURCE: bit.ly/JjFzqx

(Reporting by Elaine Lies)

 

SOURCE:  reuters.com

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จับคนไข้ให้้นอนตากแดดกลางแจ้ง รักษาวัณโรคกลับหายอย่างรวดเร็ว

หมอเมืองน้ำชากำลังเกิดความหวังว่า จะสามารถเอาแดดมาใช้รักษาโรควัณโรคได้ ซึ่งแต่ละปีโรคติดต่อเก่าแก่นี้ยังคงคร่าชีวิตผู้คนไปเกือบจะ 1.5 ล้านคน ซ้ำยังเกรงกันอยู่ว่ามันจะดื้อยาจนไม่มียาจะรักษาได้

วารสารสมาคมวิทยาศาสตร์แห่งชาติของสหรัฐฯ เปิดเผยว่า ได้มีการทดลองพบมาแล้วว่า หากรักษาโหมคนไข้ทั้งวิตามินดีและยาปฏิชีวนะจะทำให้หายเร็วขึ้น

การรักษาคนไข้วัณโรคด้วยวิตามินดี เคยใช้มาก่อนตั้งแต่ยังไม่ค้นพบยาปฏิชีวนะ โดยจะไล่คนไข้ให้ไปตากแดด ซึ่งจะทำให้ร่างกายสร้างวิตามินดีได้มากขึ้น มาเลิกไปเมื่อมีการพบยาปฏิชีวนะนี่เอง

ในการทดลองตามโรงพยาบาลแห่งต่างๆ ในกรุงลอนดอน รักษาด้วยวิตามินดีและยาปฏิชีวนะ ปรากฏว่า ทำให้คนไข้หายเร็วขึ้นเกือบ 2 อาทิตย์ ดร.เอเดรียน มาร์ติโน มหาวิทยาลัยควีน แมรี่ กล่าวว่า “ไม่ได้ใช้แทนยาปฏิชีวนะ แต่มันนับว่าเป็นอาวุธพิเศษ” และยังเผยว่า “อาจใช้รักษาโรคปอดบวมและโลหิตเป็นพิษได้อีกด้วย”.

 

ที่มา: ไทยรัฐ 7 กันยายน 2555

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Catching the rays: Vitamin D appears to dampen inflammatory responses

How basking in the sunshine could help treat patients with TB

  • Vitamin D appears to dampen inflammatory responses without affecting effect of antibiotics
  • Drug-resistant cases of Tuberculosis are on the rise in the UK

By DAILY MAIL REPORTER

PUBLISHED: 08:27 GMT, 4 September 2012

Vitamin D can speed up recovery in tuberculosis (TB) patients, say researchers.

It suggests that the 19th century practice of sending patients to retreats to soak up the sun’s rays could have done some good.

The latest study found patients recovered more quickly from the infection lung disease if they combined antibiotics with exposure to sunlight.

The findings, from Queen Mary University, suggest high doses of the vitamin dampen down the body’s inflammatory response to infection, reducing damage to the lungs.

Study leader Adrian Martineau, said: ‘Sometimes these inflammatory responses can cause tissue damage leading to … cavities in the lung.

‘If we can help these cavities to heal more quickly, then patients should be infectious for a shorter period of time, and they may also suffer less lung damage.’

The researchers also said they think vitamin D’s ability to dampen inflammatory responses without interfering with the action of antibiotics suggests supplements might be useful for patients taking antibiotics for diseases like pneumonia, sepsis and other lung infections.

TB, which people in wealthier parts of the world often mistakenly believe to be a thing of the past, is proving a tough disease to beat. In 2010, it infected 8.8 million people worldwide and killed 1.4 million.

Drug-resistant cases of Tuberculosis are on the rise in the UK, according to figures released in July. In 2010, there were 342 cases which could not be dealt with by traditional antibiotics, while in 2011, this figure rose to 431.

The infection destroys lung tissue, causing patients to cough up the bacteria which then spreads through the air and can be inhaled by others.

In recent years, rates of drug-resistant TB have been spreading fast across the world, causing alarm among public health officials and prompting calls for more research into new and more effective treatments.

The researchers, whose study was published by the Proceedings of the National Academy of Sciences on Monday, split 95 TB patients who were on standard antibiotic treatment into two groups. For the first eight weeks of their treatment, 44 of them were also given high dose vitamin D, while the remaining 51 got placebos.

Anna Coussens from Britain’s National Institute for Medical Research measured signs of inflammation in blood samples to see what effect the vitamin D had on immune responses.

‘We found that a large number of these inflammatory markers fell further and faster in patients receiving vitamin D,’ she said.

Human lung section with tuberculosis: The infection destroys lung tissue causing patients to cough up bacteria, spreading it

The researchers also found that Mycobacterium tuberculosis, the bacteria that cause TB, cleared from the phlegm coughed up from deep in the lungs faster in patients on vitamin D, taking an average of 23 days to become undetectable under the microscope compared to 36 days in those on placebo.

Martineau said it was too early to recommend all TB patients take high-dose vitamin D alongside antibiotics, as more research with a larger group of patients was needed first.

 

SOURCE:  dailymail.co.uk

อาหารเสริิมแคลเซียมกับวิตามินดี เป็นยาอายุวัฒนะของผู้สูงอายุ

นักวิทยาศาสตร์เมืองโคนมบอกแนะนำผู้สูงอายุว่า ให้กินอาหารเสริมแคลเซียมร่วมกับวิตามินดีจะช่วยให้อายุยืน ที่สำคัญต้องกินด้วยกัน วิตามินเพียงอย่างเดียวช่วยอะไรไม่ได้ผู้ช่วยศาสตราจารย์ลาร์ส เรจมาร์ค มหาวิทยาลัยแพทย์ของเดนมาร์ก รายงานในวารสารการแพทย์ “วิทยาการต่อมไร้ท่อคลินิก” ว่า ได้พบหลักฐานความสัมพันธ์อย่างเป็นเหตุเป็นผลของแคลเซียมกับวิตามินดีว่า เป็นคุณต่อสุขภาพ ทั้งคู่ได้พิสูจน์ให้เห็นแล้วว่า ช่วยป้องกันโรคกระดูกพรุน อันเป็นสาเหตุให้ผู้สูงอายุกระดูกหัก ทำให้เสียชีวิตได้

คณะของเขาได้ศึกษา ด้วยการรวบรวมข้อมูล ผู้สูงอายุวัย 70 ปี ไม่น้อยกว่า 70,000 คน พบว่า การกินวิตามินดีอย่างเดียว ไม่ทำให้ยอดผู้เสียชีวิตลดต่ำลง ต้องกินร่วมกันกับแคลเซียม จะทำให้ลดลงได้ร้อยละ 9 การกินร่วมกัน เป็นที่รู้กันว่า ช่วยให้ผู้สูงอายุกระดูกหักน้อยลง

พวกเขายังสังเกตว่า ของบำรุงทั้งสอง ไม่แต่เพียงช่วยให้กระดูกหักน้อยลงเท่านั้น หากยังช่วยบำรุงอย่างอื่นอีกด้วย.

ที่มา: ไทยรัฐ 20 มิถุนายน 2555

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Vitamin D Plus Calcium May Extend Life

But analysis doesn’t pinpoint the reasons why

By Steven Reinberg
HealthDay Reporter

FRIDAY, June 15 (HealthDay News) — Seniors who take calcium supplements along with vitamin D may lengthen their lives, a new analysis suggests.

However, only the combination of the two appears to be effective; vitamin D by itself had no benefit, the researchers noted.

“Our study provides evidence of a cause-effect relationship — that calcium and vitamin D causes beneficial effects to general health,” said study author Dr. Lars Rejnmark, an assistant professor at Aarhus University Hospital in Denmark. “Calcium with vitamin D has now been proven to reduce risk of osteoporotic fractures and death in the elderly.”

The report will be published in the August issue of the Journal of Clinical Endocrinology and Metabolism.

For the study, Rejnmark’s team collected data on more than 70,000 people who were around 70 years old and had taken part in one of eight trials that pitted vitamin D or vitamin D plus calcium against an inactive placebo by randomly assigning participants to one of the treatments.

The investigators found that, over three years, vitamin D alone did not reduce the risk of death (mortality), but when taken with calcium mortality was reduced 9 percent.

It is known that the combination of vitamin D and calcium can reduce bone fractures in older people.

However, Rejnmark’s group noted that the reduction in mortality seen in this analysis was not due to fewer fractures, but an effect of these supplements that went beyond bone health.

Recently there has been data tying calcium supplements to an increased risk of heart attack.

A study in the May edition of Heart found that calcium supplementation increased the risk of heart attack by 86 percent. But the risk was not increased with calcium from foods.

On Tuesday, the U.S. Preventive Services Task Force proposed that postmenopausal women not take low-dose calcium and vitamin D supplements daily to ward off bone fractures, because the effect is negligible.

Dr. Michael Holick, a professor of medicine, physiology and biophysics at Boston University School of Medicine, said that “other studies have shown that if you have adequate vitamin D, [it] can reduce the risk of mortality by about 7 percent.”

Although the exact mechanism of why these supplements prolong life isn’t known, Holick believes that both improve cell function and cardiovascular health, he said.

Holick also believes the task force misunderstood the data on the benefit of vitamin D and calcium. He said the amount of these supplements taken in the studies they looked at were too low to have any beneficial effect.

Knowing what to do about supplements can be confusing, Holick said. He recommends adults take 1,500 to 2,000 international units of vitamin D daily with 1,000 to 1,200 milligrams of calcium from both diet and supplements in combination.

“By doing so, you will preserve your bone health, you will improve muscle strength and you may have additional health benefits including [lowering the] risk of cardiovascular disease, certain cancers, type 2 diabetes and infectious diseases,” Holick said. “There is no downside to increasing your vitamin D intake.”

More information

For more information on calcium and vitamin D, visit the U.S. National Institutes of Health.

SOURCES: Lars Rejnmark, M.D., Ph.D., assistant professor, Aarhus University Hospital, Denmark; Michael F. Holick, M.D., Ph.D., professor, medicine, physiology and biophysics, Boston University School of Medicine; August 2012, Journal of Clinical Endocrinology and Metabolism

Last Updated: June 15, 2012

Data from: healthday